Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C49174 http://purl.obolibrary.org/obo/NCIT_C49174
Preferred Name	MK0731
Definitions	A synthetic small molecule with potential antineoplastic activity. MK0731 selectively inhibits kinesin spindle protein (KSP), which may result in the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and apoptosis in tumor cells that overexpress KSP.
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic small molecule with potential antineoplastic activity. MK0731 selectively inhibits kinesin spindle protein (KSP), which may result in the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and apoptosis in tumor cells that overexpress KSP.
label	MK0731
prefLabel	MK0731
Legacy Concept Name	MK0731
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	MK0731
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
Maps_To	MK0731
PDQ_Open_Trial_Search_ID	446551
UMLS_CUI	C1708823
FDA_UNII_Code	8HIJ5G3O02
prefixIRI	NCIT:C49174
NCI_Drug_Dictionary_ID	446551
Contributing_Source	FDA
subClassOf	http://purl.obolibrary.org/obo/NCIT_C67440
code	C49174
type	http://www.w3.org/2002/07/owl#Class
PDQ_Closed_Trial_Search_ID	446551
Semantic_Type	Organic Chemical Pharmacologic Substance
CAS_Registry	845256-65-7

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