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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49095
http://purl.obolibrary.org/obo/NCIT_C49095
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|---|---|
| Preferred Name | JNK Inhibitor CC-401 |
| Definitions |
A second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation. |
|---|---|
| prefLabel | JNK Inhibitor CC-401
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| label | JNK Inhibitor CC-401
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| NCI_META_CUI | CL937289
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| PDQ_Closed_Trial_Search_ID | 453550
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| code | C49095
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| prefixIRI | NCIT:C49095
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| in_subset | |
| Preferred_Name | JNK Inhibitor CC-401
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| FDA_UNII_Code | NOE38VQA1W
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| Contributing_Source | FDA
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| Maps_To | JNK Inhibitor CC-401
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| CAS_Registry | 395104-30-0
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| NCI_Drug_Dictionary_ID | 453550
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| Legacy Concept Name | CC-401
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 453550
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| Semantic_Type | Pharmacologic Substance
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