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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49091
http://purl.obolibrary.org/obo/NCIT_C49091
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|---|---|
| Preferred Name | Plk1 Inhibitor BI 2536 |
| Definitions |
A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. |
|---|---|
| prefLabel | Plk1 Inhibitor BI 2536
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| label | Plk1 Inhibitor BI 2536
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| PDQ_Closed_Trial_Search_ID | 452943
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| code | C49091
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| Has_Target | |
| prefixIRI | NCIT:C49091
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| in_subset |
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| Display_Name | Plk1 Inhibitor BI 2536
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| Preferred_Name | Plk1 Inhibitor BI 2536
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| FDA_UNII_Code | 4LJG22T9C6
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Plk1 Inhibitor BI 2536
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| CAS_Registry | 755038-02-9
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| NCI_Drug_Dictionary_ID | 452943
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| Legacy Concept Name | BI_2536
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It prevents cells from dividing and may block the growth of some tumors. It is a type of mitotic inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 452943
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1706888
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