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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49090
http://purl.obolibrary.org/obo/NCIT_C49090
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|---|---|
| Preferred Name | VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820 |
| Definitions |
An orally bioavailable, small molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. XL820 binds to and inhibits the receptor tyrosine kinases for vascular endothelial growth factor (VEGF), c-kit, and platelet-derived growth factor (PDGF). In tumor models of breast carcinomas, gliomas, and leukemia, this agent exhibits dose-dependent growth inhibition and has been shown to cause tumor regression.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, small molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. XL820 binds to and inhibits the receptor tyrosine kinases for vascular endothelial growth factor (VEGF), c-kit, and platelet-derived growth factor (PDGF). In tumor models of breast carcinomas, gliomas, and leukemia, this agent exhibits dose-dependent growth inhibition and has been shown to cause tumor regression. |
|---|---|
| prefLabel | VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820
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| label | VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820
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| NCI_META_CUI | CL937288
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| PDQ_Closed_Trial_Search_ID | 452042
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| code | C49090
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| prefixIRI | NCIT:C49090
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| in_subset | |
| Preferred_Name | VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820
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| Maps_To | VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820
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| NCI_Drug_Dictionary_ID | 452042
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| Legacy Concept Name | XL820
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 452042
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| Semantic_Type | Pharmacologic Substance
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