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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49087
http://purl.obolibrary.org/obo/NCIT_C49087
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|---|---|
| Preferred Name | Recombinant Modified Vaccinia Ankara-5T4 Vaccine |
| Definitions |
A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly. |
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| prefLabel | Recombinant Modified Vaccinia Ankara-5T4 Vaccine
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| label | Recombinant Modified Vaccinia Ankara-5T4 Vaccine
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| PDQ_Closed_Trial_Search_ID | 449683
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| code | C49087
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| prefixIRI | NCIT:C49087
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| in_subset |
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| Display_Name | Recombinant Modified Vaccinia Ankara-5T4 Vaccine
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| Preferred_Name | Recombinant Modified Vaccinia Ankara-5T4 Vaccine
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| FDA_UNII_Code | P258UUW1OD
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Recombinant Modified Vaccinia Ankara-5T4 Vaccine
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| NCI_Drug_Dictionary_ID | 449683
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| Legacy Concept Name | Recombinant_Modified_Vaccinia_Ankara-5T4_Vaccine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 449683
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1541801
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