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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49083
http://purl.obolibrary.org/obo/NCIT_C49083
|
|---|---|
| Preferred Name | Hemiasterlin Analog E7974 |
| Definitions |
An analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of existing microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of existing microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. |
|---|---|
| prefLabel | Hemiasterlin Analog E7974
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| label | Hemiasterlin Analog E7974
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| PDQ_Closed_Trial_Search_ID | 447049
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| code | C49083
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| prefixIRI | NCIT:C49083
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| in_subset | |
| Preferred_Name | Hemiasterlin Analog E7974
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| FDA_UNII_Code | 1BO0C11BSH
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| Contributing_Source | FDA
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| Maps_To | Hemiasterlin Analog E7974
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| CAS_Registry | 610787-07-0
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| NCI_Drug_Dictionary_ID | 447049
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| Legacy Concept Name | Hemiasterlin_Analog_7974
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 447049
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1708344
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