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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48812
http://purl.obolibrary.org/obo/NCIT_C48812
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|---|---|
| Preferred Name | Belinostat |
| Definitions |
A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. |
|---|---|
| prefLabel | Belinostat
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| label | Belinostat
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| CHEBI_ID | CHEBI:61076
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| PDQ_Closed_Trial_Search_ID | 454583
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| code | C48812
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| Has_Target | |
| prefixIRI | NCIT:C48812
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| in_subset |
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| Display_Name | Belinostat
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| Preferred_Name | Belinostat
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| FDA_UNII_Code | F4H96P17NZ
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C15H14N2O4S
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| Maps_To | Belinostat
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| CAS_Registry | 414864-00-9
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| NSC Number | 726630
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| NCI_Drug_Dictionary_ID | 454583
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| Legacy Concept Name | PXD101
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 454583
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| Accepted_Therapeutic_Use_For | relapsed or refractory peripheral T-cell lymphoma (PTCL)
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1948068
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