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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48640
http://purl.obolibrary.org/obo/NCIT_C48640
|
|---|---|
| Preferred Name | APC8015F |
| Definitions |
A cell-based vaccine composed of previously frozen autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cell-based vaccine composed of previously frozen autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. |
|---|---|
| prefLabel | APC8015F
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| label | APC8015F
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| PDQ_Closed_Trial_Search_ID | 385490
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| code | C48640
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| Has_Target | |
| prefixIRI | NCIT:C48640
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| in_subset |
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| Display_Name | APC8015F
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| Preferred_Name | APC8015F
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| Contributing_Source | CTRP
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| Maps_To | APC8015F
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| NCI_Drug_Dictionary_ID | 385490
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| Legacy Concept Name | APC8015F
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| type | |
| ALT_DEFINITION | A vaccine made from immune system cells taken from a patient with prostate cancer and frozen for future use. The cells are treated in the laboratory with a growth factor attached to a protein called prostatic-acid phosphatase (PAP), which is found on prostate cancer cells. When APC8015F is injected into the patient, it may cause T cells (a type of white blood cell) to kill tumor cells that have PAP on them.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 385490
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C1541593
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