Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C48430 http://purl.obolibrary.org/obo/NCIT_C48430
Preferred Name	Zibotentan
Definitions	An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.
Type	http://www.w3.org/2002/07/owl#Class

definition	An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.
prefLabel	Zibotentan
label	Zibotentan
PDQ_Closed_Trial_Search_ID	355727
code	C48430
Has_Target	http://purl.obolibrary.org/obo/NCIT_C71453
prefixIRI	NCIT:C48430
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Zibotentan
Preferred_Name	Zibotentan
FDA_UNII_Code	8054MM4902
Contributing_Source	CTRP FDA
Chemical_Formula	C19H16N6O4S
Maps_To	Zibotentan
CAS_Registry	186497-07-4
NCI_Drug_Dictionary_ID	355727
Legacy Concept Name	ZD4054
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called endothelin-receptor antagonists.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C28313
PDQ_Open_Trial_Search_ID	355727
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1328193

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