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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48428
http://purl.obolibrary.org/obo/NCIT_C48428
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|---|---|
| Preferred Name | Yttrium Y-90 Tacatuzumab Tetraxetan |
| Definitions |
A radioimmunoconjugate comprised of the humanized monoclonal antibody tacatuzumab, directed against alpha fetoprotein, that is conjugated to the chelating agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 tacatuzumab tetraxetan binds to tumor cells expressing alpha fetoprotein, thereby selectively delivering a cytotoxic dose of beta radiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate comprised of the humanized monoclonal antibody tacatuzumab, directed against alpha fetoprotein, that is conjugated to the chelating agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 tacatuzumab tetraxetan binds to tumor cells expressing alpha fetoprotein, thereby selectively delivering a cytotoxic dose of beta radiation. |
|---|---|
| prefLabel | Yttrium Y-90 Tacatuzumab Tetraxetan
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| label | Yttrium Y-90 Tacatuzumab Tetraxetan
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| PDQ_Closed_Trial_Search_ID | 425347
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| code | C48428
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| prefixIRI | NCIT:C48428
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| in_subset | |
| Preferred_Name | Yttrium Y-90 Tacatuzumab Tetraxetan
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| FDA_UNII_Code | GJ2416WK6Y
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| Contributing_Source | FDA
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| Chemical_Formula | C16H25N5O7.Y
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| Maps_To | Yttrium Y-90 Tacatuzumab Tetraxetan
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| CAS_Registry | 476413-07-7
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| NCI_Drug_Dictionary_ID | 425347
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| Legacy Concept Name | Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuAFP31
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of liver cancer. HuAFP31 is a monoclonal antibody that can bind to tumor cells that make a protein called alpha fetoprotein (AFP). It is linked to a radioactive substance called yttrium Y 90, which may help kill the cancer cells. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 is a type of radioimmunoconjugate.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 425347
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1541525
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