Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C48427
http://purl.obolibrary.org/obo/NCIT_C48427
Preferred Name

Larotaxel
Definitions
A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.
prefLabel
Larotaxel
label
Larotaxel
PDQ_Closed_Trial_Search_ID
42554
code
C48427
Has_Target
prefixIRI
NCIT:C48427
in_subset
Display_Name
Larotaxel
Preferred_Name
Larotaxel
FDA_UNII_Code
TWQ8K8A81Y
Contributing_Source
CTRP
FDA
Chemical_Formula
C45H53NO14
Maps_To
Larotaxel
CAS_Registry
156294-36-9
NCI_Drug_Dictionary_ID
42554
Legacy Concept Name
XRP9881
type
ALT_DEFINITION
A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42554
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0392979
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