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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48413
http://purl.obolibrary.org/obo/NCIT_C48413
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|---|---|
| Preferred Name | Opioid Growth Factor |
| Definitions |
An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05) |
|---|---|
| prefLabel | Opioid Growth Factor
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| label | Opioid Growth Factor
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| PDQ_Closed_Trial_Search_ID | 428488
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| code | C48413
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| prefixIRI | NCIT:C48413
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| in_subset | |
| Preferred_Name | Opioid Growth Factor
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| Maps_To | Opioid Growth Factor
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| NCI_Drug_Dictionary_ID | 428488
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| Legacy Concept Name | Opioid_Growth_Factor
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| type | |
| ALT_DEFINITION | A substance that relieves pain and is being studied in the treatment of some types of cancer. Opioid growth factors bind to cells in the body, including tumor cells, which have opioid growth factor receptors on the surface. This may help stop the growth of the tumor cells. It may also prevent the growth of blood vessels that tumors need to grow. An opioid growth factor is a type of biological response modifier and a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 428488
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1541553
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