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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48409
http://purl.obolibrary.org/obo/NCIT_C48409
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|---|---|
| Preferred Name | Monoclonal Antibody RAV12 |
| Definitions |
A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death. (NCI05)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death. (NCI05) |
|---|---|
| prefLabel | Monoclonal Antibody RAV12
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| label | Monoclonal Antibody RAV12
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| PDQ_Closed_Trial_Search_ID | 415732
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| code | C48409
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| prefixIRI | NCIT:C48409
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| in_subset | |
| Preferred_Name | Monoclonal Antibody RAV12
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| Maps_To | Monoclonal Antibody RAV12
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| NCI_Drug_Dictionary_ID | 415732
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| Legacy Concept Name | Monoclonal_Antibody_RAV12
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| type | |
| ALT_DEFINITION | A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. It binds to a carbohydrate (sugar) molecule that is found on gastric, colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 415732
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1541489
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