Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C48405
http://purl.obolibrary.org/obo/NCIT_C48405
Preferred Name

Lucatumumab
Definitions
A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.
prefLabel
Lucatumumab
label
Lucatumumab
PDQ_Closed_Trial_Search_ID
432936
code
C48405
Has_Target
prefixIRI
NCIT:C48405
in_subset
Display_Name
Lucatumumab
Preferred_Name
Lucatumumab
FDA_UNII_Code
P0EP9VFC4R
Contributing_Source
CTRP
FDA
Maps_To
Lucatumumab
CAS_Registry
903512-50-5
NCI_Drug_Dictionary_ID
432936
Legacy Concept Name
Monoclonal_Antibody_CHIR-12_12
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
432936
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C2980061
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