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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48385
http://purl.obolibrary.org/obo/NCIT_C48385
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|---|---|
| Preferred Name | Degarelix |
| Definitions |
A long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes. |
|---|---|
| prefLabel | Degarelix
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| label | Degarelix
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 441235
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| code | C48385
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| Has_Target | |
| prefixIRI | NCIT:C48385
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| in_subset |
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| Display_Name | Degarelix
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| Preferred_Name | Degarelix
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| FDA_UNII_Code | SX0XJI3A11
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C82H103ClN18O16
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| Maps_To | Degarelix
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| CAS_Registry | 214766-78-6
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| NCI_Drug_Dictionary_ID | 441235
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| Legacy Concept Name | Degarelix
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| type | |
| ALT_DEFINITION | A drug that is used to treat advanced prostate cancer and is also being studied in the treatment of benign prostatic hyperplasia. Degarelix binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. This causes the body to stop making testosterone, which prostate cancer needs to grow. Degarelix is a type of GnRH antagonist.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 441235
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| Accepted_Therapeutic_Use_For | advanced prostate cancer
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0971731
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