Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C48379
http://purl.obolibrary.org/obo/NCIT_C48379
Preferred Name

Cediranib Maleate
Definitions
The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
prefLabel
Cediranib Maleate
label
Cediranib Maleate
PDQ_Closed_Trial_Search_ID
425596
code
C48379
Has_Target
prefixIRI
NCIT:C48379
in_subset
Display_Name
Cediranib Maleate
Preferred_Name
Cediranib Maleate
FDA_UNII_Code
68AYS9A614
Contributing_Source
CTRP
FDA
Chemical_Formula
C25H27FN4O3.C4H4O4
Maps_To
Cediranib Maleate
CAS_Registry
857036-77-2
NSC Number
732208
NCI_Drug_Dictionary_ID
425596
Legacy Concept Name
AZD2171
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
425596
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1541530
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