Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C48374
http://purl.obolibrary.org/obo/NCIT_C48374
Preferred Name

Motesanib Diphosphate
Definitions
The orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
prefLabel
Motesanib Diphosphate
label
Motesanib Diphosphate
PDQ_Closed_Trial_Search_ID
391228
code
C48374
Has_Target
prefixIRI
NCIT:C48374
in_subset
Display_Name
Motesanib Diphosphate
Preferred_Name
Motesanib Diphosphate
FDA_UNII_Code
T6Q3060U91
Contributing_Source
CTRP
FDA
Chemical_Formula
C22H23N5O.2H3O4P
Maps_To
Motesanib Diphosphate
CAS_Registry
857876-30-3
NCI_Drug_Dictionary_ID
391228
Legacy Concept Name
AMG706
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A substance that is being studied in the treatment of some types of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein kinase inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
391228
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1541476
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