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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48369
http://purl.obolibrary.org/obo/NCIT_C48369
|
|---|---|
| Preferred Name | Multikinase Inhibitor AEE788 |
| Definitions |
An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05) |
|---|---|
| prefLabel | Multikinase Inhibitor AEE788
|
| label | Multikinase Inhibitor AEE788
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| PDQ_Closed_Trial_Search_ID | 371727
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| code | C48369
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| prefixIRI | NCIT:C48369
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| in_subset | |
| Preferred_Name | Multikinase Inhibitor AEE788
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| FDA_UNII_Code | F9JLR95I3I
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| Contributing_Source | FDA
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| Maps_To |
Multikinase Inhibitor AEE788
AEE788
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| CAS_Registry | 497839-62-0
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| NCI_Drug_Dictionary_ID | 371727
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| Legacy Concept Name | AEE788
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 371727
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1506057
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