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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48215
http://purl.obolibrary.org/obo/NCIT_C48215
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|---|---|
| Preferred Name | Poly [ADP-Ribose] Polymerase 1 |
| Definitions |
Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the regulation of various cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the regulation of various cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. |
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| prefLabel | Poly [ADP-Ribose] Polymerase 1
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| label | Poly [ADP-Ribose] Polymerase 1
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| code | C48215
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| prefixIRI | NCIT:C48215
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| OMIM_Number | 173870
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| in_subset | |
| Display_Name | Poly [ADP-Ribose] Polymerase 1
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| Preferred_Name | Poly [ADP-Ribose] Polymerase 1
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| Contributing_Source | CTRP
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| Swiss_Prot | P09874
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| Legacy Concept Name | Poly_ADP_ribose_Polymerase
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| DesignNote | Poly [ADP ribose] polymerase 1 is a cytosolic protein, and when activated is cleaved into two fragments of 89kd and 24kd.
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| type | |
| ALT_DEFINITION | An enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. Inhibitors of PARP-1 are being studied in the treatment of cancer.
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| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1567710
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