Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C482
http://purl.obolibrary.org/obo/NCIT_C482
Preferred Name

Estrogens, Conjugated
Definitions
Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04)
prefLabel
Estrogens, Conjugated
label
Estrogens, Conjugated
PDQ_Closed_Trial_Search_ID
39237
code
C482
prefixIRI
NCIT:C482
in_subset
Preferred_Name
Estrogens, Conjugated
FDA_UNII_Code
IU5QR144QX
Contributing_Source
FDA
Maps_To
Estrogens, Conjugated
CAS_Registry
12126-59-9
NSC Number
18313
NCI_Drug_Dictionary_ID
39237
Legacy Concept Name
Conjugated_Estrogens
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39237
Accepted_Therapeutic_Use_For
Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0014938
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display