loading...| Preferred Name | Cholecalciferol | |
| Synonyms |
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| Definitions |
A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C48194 |
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| ALT_DEFINITION |
Vitamin D synthesized from ergosterol in yeast and plants. A nutrient that the body needs in small amounts to function and stay healthy. Cholecalciferol helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, egg yolks, and dairy products. Skin exposed to sunshine can also make cholecalciferol. Not enough cholecalciferol can cause a bone disease called rickets. It is being studied in the prevention and treatment of some types of cancer. |
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| CAS_Registry |
67-97-0 |
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| CHEBI_ID |
CHEBI:28940 |
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| Chemical_Formula |
C27H44O |
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| code |
C48194 |
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| Contributing_Source |
CRCH CTRP FDA |
|
| definition |
A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption. |
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| Display_Name |
Cholecalciferol |
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| FDA_UNII_Code |
1C6V77QF41 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Cholecalciferol |
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| Legacy Concept Name |
Cholecalciferol |
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| NCI_Drug_Dictionary_ID |
39734 |
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| NSC Number |
375571 |
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| PDQ_Closed_Trial_Search_ID |
39734 |
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| PDQ_Open_Trial_Search_ID |
39734 |
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| Preferred_Name |
Cholecalciferol |
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| prefixIRI |
NCIT:C48194 |
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| prefLabel |
Cholecalciferol |
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| Semantic_Type |
Pharmacologic Substance Vitamin |
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| UMLS_CUI |
C0008318 |
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| Unit |
mcg |
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| subClassOf |