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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C48011
http://purl.obolibrary.org/obo/NCIT_C48011
|
|---|---|
| Preferred Name | Phenytoin Sodium |
| Definitions |
The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission. This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission. This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity. |
|---|---|
| prefLabel | Phenytoin Sodium
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| label | Phenytoin Sodium
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| code | C48011
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| prefixIRI | NCIT:C48011
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| in_subset | |
| Preferred_Name | Phenytoin Sodium
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| FDA_UNII_Code | 4182431BJH
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| Contributing_Source | FDA
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| Chemical_Formula | C15H11N2O2.Na
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| Maps_To | Phenytoin Sodium
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| CAS_Registry | 630-93-3
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| NSC Number | 8722
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| Legacy Concept Name | Phenytoin_Sodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used to treat or prevent seizures or convulsions that may be caused by epilepsy, brain surgery, or treatment for brain cancer. It is a type of anticonvulsant agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0237417
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