loading...| Preferred Name |
Estramustine Phosphate Sodium |
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| Synonyms |
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| Definitions |
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C480 |
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| CAS_Registry |
52205-73-9 |
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| CHEBI_ID |
CHEBI:31562 |
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| Chemical_Formula |
C23H30Cl2NO6P.2Na |
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| code |
C480 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. |
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| Display_Name |
Estramustine Phosphate Sodium |
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| FDA_UNII_Code |
75F375MT2N |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Estramustine Phosphate Sodium |
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| Legacy Concept Name |
Estramustine_Phosphate_Sodium |
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| Maps_To |
Estramustine Phosphate Sodium |
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| NCI_Drug_Dictionary_ID |
39235 |
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| NSC Number |
89199 |
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| PDQ_Closed_Trial_Search_ID |
39235 |
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| PDQ_Open_Trial_Search_ID |
39235 |
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| Preferred_Name |
Estramustine Phosphate Sodium |
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| prefixIRI |
NCIT:C480 |
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| prefLabel |
Estramustine Phosphate Sodium |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0014922 |
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| subClassOf |