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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C479
http://purl.obolibrary.org/obo/NCIT_C479
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|---|---|
| Preferred Name | Estramustine |
| Definitions |
A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04) |
|---|---|
| prefLabel | Estramustine
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| label | Estramustine
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| CHEBI_ID | CHEBI:4868
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| code | C479
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| prefixIRI | NCIT:C479
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| in_subset | |
| Preferred_Name | Estramustine
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| FDA_UNII_Code | 35LT29625A
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| Contributing_Source | FDA
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| Chemical_Formula | C23H31Cl2NO3
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| Maps_To | Estramustine
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| CAS_Registry | 2998-57-4
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| NSC Number | 89201
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| Legacy Concept Name | Estramustine
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| type | |
| ALT_DEFINITION | A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Prostate Neoplasm
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0014921
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