Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Therapeutic Estradiol
Synonyms
Definitions

A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females, that may be used as hormone replacement therapy. Typically esterified, estradiol derivatives are formulated for oral, intravaginal, transdermal, or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. It may play a role in immune and inflammatory processes.
ID

http://purl.obolibrary.org/obo/NCIT_C478
CAS_Registry

50-28-2
CHEBI_ID

CHEBI:16469
Chemical_Formula

C18H24O2
code

C478
Contributing_Source

CTRP

FDA
definition

A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females, that may be used as hormone replacement therapy. Typically esterified, estradiol derivatives are formulated for oral, intravaginal, transdermal, or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. It may play a role in immune and inflammatory processes.
Display_Name

Therapeutic Estradiol
FDA_UNII_Code

4TI98Z838E
Has_Target

http://purl.obolibrary.org/obo/NCIT_C38361
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Therapeutic Estradiol
Legacy Concept Name

Therapeutic_Estradiol
Maps_To

Therapeutic Estradiol
NCI_Drug_Dictionary_ID

39236
NSC Number

20293

9895
PDQ_Closed_Trial_Search_ID

39236
PDQ_Open_Trial_Search_ID

39236
Preferred_Name

Therapeutic Estradiol
prefixIRI

NCIT:C478
prefLabel

Therapeutic Estradiol
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0699359
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2181
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