loading...| Preferred Name | Therapeutic Estradiol | |
| Synonyms |
|
|
| Definitions |
A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females, that may be used as hormone replacement therapy. Typically esterified, estradiol derivatives are formulated for oral, intravaginal, transdermal, or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. It may play a role in immune and inflammatory processes. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C478 |
|
| CAS_Registry |
50-28-2 |
|
| CHEBI_ID |
CHEBI:16469 |
|
| Chemical_Formula |
C18H24O2 |
|
| code |
C478 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females, that may be used as hormone replacement therapy. Typically esterified, estradiol derivatives are formulated for oral, intravaginal, transdermal, or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. It may play a role in immune and inflammatory processes. |
|
| Display_Name |
Therapeutic Estradiol |
|
| FDA_UNII_Code |
4TI98Z838E |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
|
| Is_Value_For_GDC_Property | ||
| label |
Therapeutic Estradiol |
|
| Legacy Concept Name |
Therapeutic_Estradiol |
|
| Maps_To |
Therapeutic Estradiol |
|
| NCI_Drug_Dictionary_ID |
39236 |
|
| NSC Number |
20293 9895 |
|
| PDQ_Closed_Trial_Search_ID |
39236 |
|
| PDQ_Open_Trial_Search_ID |
39236 |
|
| Preferred_Name |
Therapeutic Estradiol |
|
| prefixIRI |
NCIT:C478 |
|
| prefLabel |
Therapeutic Estradiol |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0699359 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C478 | GSSO | SAME_URI | |
| http://purl.obolibrary.org/obo/NCIT_C478 | GSSO | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C478 | NCIT | LOOM | |
| http://purl.bioontology.org/ontology/PDQ/CDR0000039236 | PDQ | LOOM |