Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Potassium Perchlorate
Synonyms
Definitions

The potassium salt of perchloric acid and a member of the Hofmeister ions series with thyroid blocking properties. Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3). In addition, this agent decreases the accumulation of the radioactive imaging substance and Hofmeister series ion, pertechnetate Tc 99m, in the choroid plexus and in the salivary and thyroid glands through competitive displacing.
ID

http://purl.obolibrary.org/obo/NCIT_C47681
CAS_Registry

7778-74-7
Chemical_Formula

ClO4.K
code

C47681
Contributing_Source

FDA
definition

The potassium salt of perchloric acid and a member of the Hofmeister ions series with thyroid blocking properties. Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3). In addition, this agent decreases the accumulation of the radioactive imaging substance and Hofmeister series ion, pertechnetate Tc 99m, in the choroid plexus and in the salivary and thyroid glands through competitive displacing.
FDA_UNII_Code

42255P5X4D
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Potassium Perchlorate
Legacy Concept Name

Potassium_Perchlorate
NSC Number

41873
Preferred_Name

Potassium Perchlorate
prefixIRI

NCIT:C47681
prefLabel

Potassium Perchlorate
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0071774
subClassOf

http://purl.obolibrary.org/obo/NCIT_C885
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