loading...| Preferred Name | Nitazoxanide | |
| Synonyms |
|
|
| Definitions |
A synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47637 |
|
| CAS_Registry |
55981-09-4 |
|
| Chemical_Formula |
C12H9N3O5S |
|
| code |
C47637 |
|
| Contributing_Source |
FDA |
|
| definition |
A synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum. |
|
| FDA_UNII_Code |
SOA12P041N |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
|
| label |
Nitazoxanide |
|
| Legacy Concept Name |
Nitazoxanide |
|
| NCI_Drug_Dictionary_ID |
769610 |
|
| NSC Number |
697855 |
|
| PDQ_Closed_Trial_Search_ID |
769610 |
|
| PDQ_Open_Trial_Search_ID |
769610 |
|
| Preferred_Name |
Nitazoxanide |
|
| prefixIRI |
NCIT:C47637 |
|
| prefLabel |
Nitazoxanide |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0068788 |
|
| subClassOf |