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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Methyldopa | |
| Synonyms |
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| Definitions |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47616 |
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| CAS_Registry |
41372-08-1
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|
| CHEBI_ID |
CHEBI:61058
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| Chemical_Formula |
2C10H13NO4.3H2O
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| code |
C47616
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| Contributing_Source |
FDA
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|
| definition |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
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| FDA_UNII_Code |
56LH93261Y
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| in_subset | ||
| label |
Methyldopa
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| Legacy Concept Name |
Methyldopa
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| NSC Number |
169916
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| Preferred_Name |
Methyldopa
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| prefixIRI |
NCIT:C47616
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| prefLabel |
Methyldopa
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0025741
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| subClassOf |
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