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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Insulin Glargine | |
| Synonyms |
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| Definitions |
A recombinant human insulin analog with long-acting, blood glucose-lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin glargine inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin glargine also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47564 |
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| ALT_DEFINITION |
A drug used to control the amount of sugar in the blood of patients with diabetes. It is a form of the hormone insulin that is made in the laboratory. Insulin glargine controls blood sugar longer than insulin does. It is a type of therapeutic insulin.
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| CAS_Registry |
160337-95-1
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| Chemical_Formula |
C267H404N72O78S6
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| code |
C47564
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| Contributing_Source |
CTRP FDA
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| definition |
A recombinant human insulin analog with long-acting, blood glucose-lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin glargine inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin glargine also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05)
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| Display_Name |
Insulin Glargine
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| FDA_UNII_Code |
2ZM8CX04RZ
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Insulin Glargine
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| Legacy Concept Name |
Insulin_Glargine_Recombinant
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| NCI_Drug_Dictionary_ID |
561310
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| PDQ_Closed_Trial_Search_ID |
561310
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| PDQ_Open_Trial_Search_ID |
561310
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| Preferred_Name |
Insulin Glargine
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| prefixIRI |
NCIT:C47564
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| prefLabel |
Insulin Glargine
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0907402
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| subClassOf |
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