Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C47471
http://purl.obolibrary.org/obo/NCIT_C47471
Preferred Name

Daunorubicin Citrate
Definitions
A semi-synthetic anthracycline glycoside antibiotic obtained from Streptomyces with antineoplastic activity. Daunorubicin citrate intercalates DNA, which leads to inhibition of DNA and RNA synthesis, and consequently blocks cell division and results in apoptosis. This anti-tumor antibiotic is most active in the S phase of cell division. Daunorubicin is indicated in the treatment of a wide variety of cancers including acute non-lymphocytic leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor, and chronic myelocytic leukemia. (NCI05)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A semi-synthetic anthracycline glycoside antibiotic obtained from Streptomyces with antineoplastic activity. Daunorubicin citrate intercalates DNA, which leads to inhibition of DNA and RNA synthesis, and consequently blocks cell division and results in apoptosis. This anti-tumor antibiotic is most active in the S phase of cell division. Daunorubicin is indicated in the treatment of a wide variety of cancers including acute non-lymphocytic leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor, and chronic myelocytic leukemia. (NCI05)
prefLabel
Daunorubicin Citrate
label
Daunorubicin Citrate
code
C47471
prefixIRI
NCIT:C47471
in_subset
Preferred_Name
Daunorubicin Citrate
FDA_UNII_Code
5L84T2Z6NP
Contributing_Source
FDA
Chemical_Formula
C27H29NO10.C6H8O7
Maps_To
Daunorubicin Citrate
CAS_Registry
371770-68-2
Legacy Concept Name
Daunorubicin_Citrate
Has_Free_Acid_Or_Base_Form
type
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1289972
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