Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C474
http://purl.obolibrary.org/obo/NCIT_C474
Preferred Name

Epirubicin Hydrochloride
Definitions
The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
prefLabel
Epirubicin Hydrochloride
label
Epirubicin Hydrochloride
PDQ_Closed_Trial_Search_ID
39232
code
C474
prefixIRI
NCIT:C474
in_subset
Display_Name
Epirubicin Hydrochloride
Preferred_Name
Epirubicin Hydrochloride
FDA_UNII_Code
22966TX7J5
Contributing_Source
CTRP
FDA
Chemical_Formula
C27H29NO11.HCl
Maps_To
Epirubicin Hydrochloride
CAS_Registry
56390-09-1
NSC Number
256942
NCI_Drug_Dictionary_ID
39232
Legacy Concept Name
Epirubicin
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Ellence is a type of anthracycline antibiotic.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39232
Accepted_Therapeutic_Use_For
Breast cancer
Semantic_Type
Organic Chemical
Pharmacologic Substance
Antibiotic
UMLS_CUI
C0700582
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