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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C45515
http://purl.obolibrary.org/obo/NCIT_C45515
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|---|---|
| Preferred Name | Recombinant Human Endostatin |
| Definitions |
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature. (NCI04) |
|---|---|
| prefLabel | Recombinant Human Endostatin
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| label | Recombinant Human Endostatin
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| PDQ_Closed_Trial_Search_ID | 459758
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| code | C45515
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| prefixIRI | NCIT:C45515
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| in_subset | |
| Preferred_Name | Recombinant Human Endostatin
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| FDA_UNII_Code | 67RHC0R671
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| Contributing_Source | FDA
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| Maps_To | Recombinant Human Endostatin
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| NCI_Drug_Dictionary_ID | 459758
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| Legacy Concept Name | Recombinant_Endostatin
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. Endostatin is made from a type of collagen (a protein found in cartilage and other connective tissue). It may prevent the growth of new blood vessels that tumors need to grow. Endostatin is a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 459758
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| Is_Related_To_Endogenous_Product | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1705207
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