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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C446
http://purl.obolibrary.org/obo/NCIT_C446
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|---|---|
| Preferred Name | Distamycin Antineoplastic Antibiotic |
| Definitions |
An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities. |
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| label | Distamycin Antineoplastic Antibiotic
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| prefLabel | Distamycin Antineoplastic Antibiotic
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| Legacy Concept Name | Distamycin_Antibiotic
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| Preferred_Name | Distamycin Antineoplastic Antibiotic
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| UMLS_CUI | C0012750
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| prefixIRI | NCIT:C446
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| subClassOf | |
| code | C446
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| type | |
| Semantic_Type | Chemical Viewed Functionally
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