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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ditiocarb | |
| Synonyms |
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|
| Definitions |
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C432 |
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| CAS_Registry |
147-84-2
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|
| Chemical_Formula |
C5H11NS2
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|
| code |
C432
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|
| Contributing_Source |
FDA
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|
| definition |
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)
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| FDA_UNII_Code |
99Z2744345
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Ditiocarb
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|
| Legacy Concept Name |
Diethyldithiocarbamate
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|
| Maps_To |
Ditiocarb
|
|
| NCI_Drug_Dictionary_ID |
40247
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|
| PDQ_Closed_Trial_Search_ID |
40247
|
|
| PDQ_Open_Trial_Search_ID |
40247
|
|
| Preferred_Name |
Ditiocarb
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|
| prefixIRI |
NCIT:C432
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| prefLabel |
Ditiocarb
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0012194
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| subClassOf |
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