Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C430 http://purl.obolibrary.org/obo/NCIT_C430
Preferred Name	Zalcitabine
Definitions	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04)
prefLabel	Zalcitabine
label	Zalcitabine
CHEBI_ID	CHEBI:10101
PDQ_Closed_Trial_Search_ID	40349
code	C430
prefixIRI	NCIT:C430
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Zalcitabine
FDA_UNII_Code	6L3XT8CB3I
Contributing_Source	FDA
Chemical_Formula	C9H13N3O3
Maps_To	Zalcitabine
CAS_Registry	7481-89-2
NSC Number	606170
NCI_Drug_Dictionary_ID	40349
Legacy Concept Name	Zalcitabine
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1660
PDQ_Open_Trial_Search_ID	40349
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI	C0012132

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