Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C422
http://purl.obolibrary.org/obo/NCIT_C422
Preferred Name

Dexamethasone
Definitions
A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
prefLabel
Dexamethasone
label
Dexamethasone
CHEBI_ID
CHEBI:41879
PDQ_Closed_Trial_Search_ID
39789
code
C422
Has_Target
prefixIRI
NCIT:C422
in_subset
Display_Name
Dexamethasone
Preferred_Name
Dexamethasone
FDA_UNII_Code
7S5I7G3JQL
Contributing_Source
CTRP
DIPG/DMG
FDA
PCDC
Chemical_Formula
C22H29FO5
Maps_To
Dexamethasone
CAS_Registry
50-02-2
NSC Number
34521
NCI_Drug_Dictionary_ID
39789
Legacy Concept Name
Dexamethasone
type
ALT_DEFINITION
A synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39789
Accepted_Therapeutic_Use_For
Allergic disorders; antiemetic; corneal injury; inflammatory conditions
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0011777
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