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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C41625
http://purl.obolibrary.org/obo/NCIT_C41625
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|---|---|
| Preferred Name | Protein Kinase B |
| Definitions |
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. |
|---|---|
| prefLabel | Protein Kinase B
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| label | Protein Kinase B
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| code | C41625
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| prefixIRI | NCIT:C41625
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| in_subset | |
| Display_Name | Protein Kinase B
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| Preferred_Name | Protein Kinase B
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| Contributing_Source | CTRP
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| Legacy Concept Name | Protein_Kinase_B
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| type | |
| ALT_DEFINITION | A group of enzymes involved in several processes related to cell growth and survival. Protein kinase B enzymes help to transfer signals inside cells. A protein kinase B enzyme is a type of serine/threonine protein kinase.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0164786
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