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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Deferoxamine | |
| Synonyms |
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| Definitions |
An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C416 |
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| ALT_DEFINITION |
An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.
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| CAS_Registry |
70-51-9
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| CHEBI_ID |
CHEBI:4356
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| Chemical_Formula |
C25H48N6O8
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|
| code |
C416
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| Contributing_Source |
CTRP FDA
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| definition |
An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
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| Display_Name |
Deferoxamine
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| FDA_UNII_Code |
J06Y7MXW4D
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Deferoxamine
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| Legacy Concept Name |
Deferoxamine
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| Maps_To |
Deferoxamine
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| NSC Number |
527604
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| Preferred_Name |
Deferoxamine
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| prefixIRI |
NCIT:C416
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| prefLabel |
Deferoxamine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0011145
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| subClassOf |
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