Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C416
http://purl.obolibrary.org/obo/NCIT_C416
Preferred Name

Deferoxamine
Definitions
An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
prefLabel
Deferoxamine
label
Deferoxamine
Has_Salt_Form
CHEBI_ID
CHEBI:4356
code
C416
Has_Target
prefixIRI
NCIT:C416
in_subset
Display_Name
Deferoxamine
Preferred_Name
Deferoxamine
FDA_UNII_Code
J06Y7MXW4D
Contributing_Source
CTRP
FDA
Chemical_Formula
C25H48N6O8
Maps_To
Deferoxamine
CAS_Registry
70-51-9
NSC Number
527604
Legacy Concept Name
Deferoxamine
type
ALT_DEFINITION
An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0011145
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