Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C412
http://purl.obolibrary.org/obo/NCIT_C412
Preferred Name

Dactinomycin
Definitions
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
prefLabel
Dactinomycin
label
Dactinomycin
CHEBI_ID
CHEBI:27666
PDQ_Closed_Trial_Search_ID
39675
code
C412
prefixIRI
NCIT:C412
in_subset
Display_Name
Dactinomycin
Preferred_Name
Dactinomycin
FDA_UNII_Code
1CC1JFE158
Contributing_Source
CTRP
FDA
PCDC
Chemical_Formula
C62H86N12O16
Maps_To
Dactinomycin
CAS_Registry
50-76-0
NSC Number
3053
NCI_Drug_Dictionary_ID
39675
Legacy Concept Name
Dactinomycin
Is_PCDC_GCT_Permissible_Value_For_Variable
type
ALT_DEFINITION
An anticancer drug that is a type of antitumor antibiotic.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39675
Accepted_Therapeutic_Use_For
Wilms' tumor; rhabdomyosarcoma; Ewing's sarcoma; testicular cancer; gestational trophoblastic neoplasia; choriocarcinoma; melanoma; neuroblastoma; retinoblastoma; uterine sarcomas; Kaposi's sarcoma; sarcoma botryoides; soft tissue sarcoma.
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
UMLS_CUI
C0010934
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