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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C411
http://purl.obolibrary.org/obo/NCIT_C411
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|---|---|
| Preferred Name | Dacarbazine |
| Definitions |
A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|---|---|
| prefLabel | Dacarbazine
|
| label | Dacarbazine
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| CHEBI_ID | CHEBI:4305
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| PDQ_Closed_Trial_Search_ID | 39768
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| code | C411
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| prefixIRI | NCIT:C411
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| in_subset |
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| Display_Name | Dacarbazine
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| Preferred_Name | Dacarbazine
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| FDA_UNII_Code | 7GR28W0FJI
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C6H10N6O
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| Maps_To | Dacarbazine
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| CAS_Registry | 4342-03-4
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| NSC Number | 45388
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| NCI_Drug_Dictionary_ID | 39768
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| Legacy Concept Name | Dacarbazine
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| type | |
| ALT_DEFINITION | A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39768
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| Accepted_Therapeutic_Use_For | Carcinoid cancer; Hodgkins disease; Islet cell carcinoma; Melanoma; Neuroblastoma; Soft tissue sarcoma
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0010927
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