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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C41017
http://purl.obolibrary.org/obo/NCIT_C41017
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|---|---|
| Preferred Name | Growth Hormone Receptor |
| Definitions |
Growth hormone receptor (638 aa, ~72 kDa) is encoded by the human GHR gene. This protein is involved in somatotropin-dependent signaling and generalized growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Growth hormone receptor (638 aa, ~72 kDa) is encoded by the human GHR gene. This protein is involved in somatotropin-dependent signaling and generalized growth. |
|---|---|
| prefLabel | Growth Hormone Receptor
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| label | Growth Hormone Receptor
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| code | C41017
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| prefixIRI | NCIT:C41017
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| OMIM_Number | 600946
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| in_subset | |
| Display_Name | Growth Hormone Receptor
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| Preferred_Name | Growth Hormone Receptor
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| Contributing_Source | CTRP
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| Swiss_Prot | P10912
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| Legacy Concept Name | Growth_Hormone_Receptor
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| DesignNote | Growth hormone receptor is a type I membrane receptor for growth hormone with a ligand-binding extracellular domain (GHBP); a FnIII domain; a WSXWS motif; a cytoplasmic UbE motif for ubiquitination and internalization; and a cytoplasmic JAK interaction box 1 motif.
Growth hormone receptor can undergo cleavage after amino acid residue 253, which removes the transmembrane domain and produces a soluble protein called growth hormone-binding protein (GH-binding protein; GHBP; serum-binding protein). Growth hormone-binding protein plays a role as a reservoir of somatotropin in the plasma.
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0034839
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