Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C408
http://purl.obolibrary.org/obo/NCIT_C408
Preferred Name

Cytarabine
Definitions
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)
prefLabel
Cytarabine
label
Cytarabine
Has_Salt_Form
CHEBI_ID
CHEBI:28680
PDQ_Closed_Trial_Search_ID
39015
code
C408
prefixIRI
NCIT:C408
in_subset
Display_Name
Cytarabine
Preferred_Name
Cytarabine
FDA_UNII_Code
04079A1RDZ
Is_PCDC_AML_Permissible_Value_For_Variable
Contributing_Source
CTRP
FDA
PCDC
Chemical_Formula
C9H13N3O5
Maps_To
Cytarabine
CAS_Registry
147-94-4
NSC Number
287459
NCI_Drug_Dictionary_ID
39015
Legacy Concept Name
Cytosine_Arabinoside
type
ALT_DEFINITION
A drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39015
Accepted_Therapeutic_Use_For
Acute lymphocytic leukemia; Acute Nonlymphocytic leukemia; Bone marrow transplantation; Carcinomatous meningitis; Chronic myelogenous leukemia; Hogkins disease;
Meningeal leukemia; Acute Myeloid Leukemia; Meningitis lymphomatous; Myelodysplasic syndrome; Non-Hodgkins lymphoma; Ovarian cancer, intraperitoneal treatment; Retinoblastoma
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C0010711
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