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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/NCIT_C405
http://purl.obolibrary.org/obo/NCIT_C405
|
|---|---|
| Preferred Name | Cyclophosphamide |
| Definitions |
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. |
|---|---|
| label |
Cyclophosphamide
|
| prefLabel |
Cyclophosphamide
|
| Legacy Concept Name |
Cyclophosphamide
|
| in_subset |
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|
| Preferred_Name |
Cyclophosphamide
|
| Is_Value_For_GDC_Property | |
| Is_PCDC_GCT_Permissible_Value_For_Variable | |
| Chemical_Formula |
C7H15Cl2N2O2P.H2O
|
| Display_Name |
Cyclophosphamide
|
| Maps_To |
Cyclophosphamide
|
| PDQ_Open_Trial_Search_ID |
39748
|
| UMLS_CUI |
C0010583
|
| FDA_UNII_Code |
8N3DW7272P
|
| prefixIRI |
NCIT:C405
|
| Accepted_Therapeutic_Use_For |
Breast cancer; Leukemias; Lupus nephritis; Lymphoma; Multiple myeloma; Neuroblastoma; Nephrotic syndrome; Ovarian cancer; Retinoblastoma; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia
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| NCI_Drug_Dictionary_ID |
39748
|
| Contributing_Source |
CTRP
FDA
GDC
PCDC
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| subClassOf | |
| CHEBI_ID |
CHEBI:4026
|
| Is_PCDC_AML_Permissible_Value_For_Variable | |
| code |
C405
|
| type | |
| ALT_DEFINITION |
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
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| NSC Number |
26271
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| PDQ_Closed_Trial_Search_ID |
39748
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry |
6055-19-2
|
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