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Biological and Environmental Research Ontology
| Preferred Name | Cycloleucine | |
| Synonyms |
|
|
| Definitions |
A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C404 |
|
| CAS_Registry |
52-52-8
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|
| Chemical_Formula |
C6H11NO2
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|
| code |
C404
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|
| Contributing_Source |
FDA
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|
| definition |
A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.
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| FDA_UNII_Code |
0TQU7668EI
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Cycloleucine
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|
| Legacy Concept Name |
Cycloleucine
|
|
| Maps_To |
Cycloleucine
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| NCI_Drug_Dictionary_ID |
39200
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|
| NSC Number |
1026
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| PDQ_Closed_Trial_Search_ID |
39200
|
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| PDQ_Open_Trial_Search_ID |
39200
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|
| Preferred_Name |
Cycloleucine
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| prefixIRI |
NCIT:C404
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| prefLabel |
Cycloleucine
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0010575
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| subClassOf |
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