Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C398
http://purl.obolibrary.org/obo/NCIT_C398
Preferred Name

Diltiazem Hydrochloride
Definitions
A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)
prefLabel
Diltiazem Hydrochloride
label
Diltiazem Hydrochloride
CHEBI_ID
CHEBI:645509
PDQ_Closed_Trial_Search_ID
40122
code
C398
prefixIRI
NCIT:C398
in_subset
Preferred_Name
Diltiazem Hydrochloride
FDA_UNII_Code
OLH94387TE
Contributing_Source
FDA
Chemical_Formula
C22H26N2O4S.HCl
CAS_Registry
33286-22-5
NCI_Drug_Dictionary_ID
40122
Legacy Concept Name
Diltiazem_Hydrochloride
Has_Free_Acid_Or_Base_Form
type
subClassOf
PDQ_Open_Trial_Search_ID
40122
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0700940
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