Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C394
http://purl.obolibrary.org/obo/NCIT_C394
Preferred Name

Therapeutic Corticotropin-Releasing Factor
Definitions
Any synthetic therapeutic agent which is chemically identical to or similar to the endogenous human corticotropin-releasing factor (hCRF). Synthesized in the hypothalamus, hCRF stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH). In cerebral edema, hCRF acts by impeding the flow of fluid from blood vessels into brain tissue, thereby decreasing edema and stabilizing intracranial pressure. This agent possesses anti-edema properties independent of adrenal gland function. (NCI05)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Any synthetic therapeutic agent which is chemically identical to or similar to the endogenous human corticotropin-releasing factor (hCRF). Synthesized in the hypothalamus, hCRF stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH). In cerebral edema, hCRF acts by impeding the flow of fluid from blood vessels into brain tissue, thereby decreasing edema and stabilizing intracranial pressure. This agent possesses anti-edema properties independent of adrenal gland function. (NCI05)
prefLabel
Therapeutic Corticotropin-Releasing Factor
label
Therapeutic Corticotropin-Releasing Factor
NCI_META_CUI
CL324578
code
C394
prefixIRI
NCIT:C394
in_subset
Preferred_Name
Therapeutic Corticotropin-Releasing Factor
FDA_UNII_Code
305OE8862Y
Contributing_Source
FDA
Chemical_Formula
C208H344N60O63S2
CAS_Registry
86784-80-7
Legacy Concept Name
Therapeutic_Corticotropin_Releasing_Factor
type
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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