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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38991
http://purl.obolibrary.org/obo/NCIT_C38991
|
|---|---|
| Preferred Name | GM-CSF Receptor |
| Definitions |
Heterodimeric human GM-CSF Receptor is composed of Colony Stimulating Factor 2 Receptor Alpha Chain and Colony Stimulating Factor 2 Receptor Beta Chain. CSF2RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. The receptor signal transducing beta chain is common to the high affinity IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Heterodimeric human GM-CSF Receptor is composed of Colony Stimulating Factor 2 Receptor Alpha Chain and Colony Stimulating Factor 2 Receptor Beta Chain. CSF2RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. The receptor signal transducing beta chain is common to the high affinity IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI) |
|---|---|
| label | GM-CSF Receptor
|
| prefLabel | GM-CSF Receptor
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| Legacy Concept Name | GM-CSF_Receptor
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| in_subset | |
| Preferred_Name | GM-CSF Receptor
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| Display_Name | GM-CSF Receptor
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| UMLS_CUI | C0080091
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| prefixIRI | NCIT:C38991
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C38991
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| type | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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