Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38967
http://purl.obolibrary.org/obo/NCIT_C38967
|
|---|---|
| Preferred Name | Mucin-1 |
| Definitions |
Mucin-1 (1255 aa, ~122 kDa) is encoded by the human MUC1 gene. This protein plays a role in both signaling and cell adhesion.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Mucin-1 (1255 aa, ~122 kDa) is encoded by the human MUC1 gene. This protein plays a role in both signaling and cell adhesion. |
|---|---|
| prefLabel | Mucin-1
|
| label | Mucin-1
|
| code | C38967
|
| prefixIRI | NCIT:C38967
|
| OMIM_Number | 158340
|
| in_subset | |
| Display_Name | Mucin-1
|
| Preferred_Name | Mucin-1
|
| Gene_Encodes_Product | NM_002456
|
| Contributing_Source | CTRP
|
| Swiss_Prot | P15941
|
| Legacy Concept Name | Mucin-1
|
| DesignNote | Mucin-1 is cleaved into Mucin-1 subunit alpha (MUC1-NT or MUC1-alpha) and Mucin-1 subunit beta (MUC1-beta or MUC1-CT). (UniProt)
Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. This protein is expressed as at least 10 isoforms produced by alternative splicing. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.
|
| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
|
| UMLS_CUI | C0057628
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |