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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38919
http://purl.obolibrary.org/obo/NCIT_C38919
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|---|---|
| Preferred Name | Interleukin-12 Receptor Subunit Beta-2 |
| Definitions |
Interleukin-12 receptor subunit beta-2 (862 aa, ~97 kDa) is encoded by the human IL12RB2 gene. This protein is involved in the modulation of interleukin-12-mediated signaling.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Interleukin-12 receptor subunit beta-2 (862 aa, ~97 kDa) is encoded by the human IL12RB2 gene. This protein is involved in the modulation of interleukin-12-mediated signaling. |
|---|---|
| label | Interleukin-12 Receptor Subunit Beta-2
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| prefLabel | Interleukin-12 Receptor Subunit Beta-2
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| Legacy Concept Name | Interleukin-12-Receptor_Beta-2-Chain
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| in_subset | |
| Preferred_Name | Interleukin-12 Receptor Subunit Beta-2
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| Display_Name | Interleukin-12 Receptor Subunit Beta-2
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| Swiss_Prot | Q99665
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| DesignNote | Interleukin-12 receptor subunit beta-1 is a type I transmembrane disulfide-linked dimer/oligomer containing 5 fibronectin type-III domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of IL12RB1 and IL12RB2. (UniProt)
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| UMLS_CUI | C1701820
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| prefixIRI | NCIT:C38919
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C38919
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| type | |
| OMIM_Number | 601642
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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